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Finally, while this narrative review provides an overview of the evidence, a systematic review with a comprehensive search strategy, critical appraisal of included studies, and synthesis of findings, would have provided a more conclusive evidence base and hence would be warranted

Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39

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